Microfluidic System for Multichannel Optical Measurement of Shear-induced Platelet Thrombosis in Unfractionated Blood
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چکیده
We report on development of a microfluidic device and optical system for measurement of occlusive platelet thrombosis at initial shear rates ranging from physiological to pathological conditions from (500 – 13000 s) within four stenotic channels in unfractionated blood. Real-time, label-free measurement of platelet thrombosis was performed by measuring optical radiation transmitted transversely through flow channels. Occlusive thrombosis occurred at shear rates above 4000 s and measurements showed average differences in of 8.4% and 3.97% compared with traditional flow-rate and white-light microscopy methods, respectively.
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تاریخ انتشار 2011